Fariba Sadeghi; Seyed Mohammad Bagher Fazljou; Bita Sepehri; Laleh Khodaie; Hassan Monirifar
Volume 22, Issue 6 , 2020
Abstract
Background: The cardinal symptoms of gastroesophageal reflux disease include heartburn (pyrosis) and regurgitation. Conven- tional treatment is done by proton pump inhibitors. In Persian traditional medicine, several herbs (single or combined) have been used to treat gastrointestinal disorders.
Objectives: ...
Read More
Background: The cardinal symptoms of gastroesophageal reflux disease include heartburn (pyrosis) and regurgitation. Conven- tional treatment is done by proton pump inhibitors. In Persian traditional medicine, several herbs (single or combined) have been used to treat gastrointestinal disorders.
Objectives: This study aimed to assess the effects of Pistacia lentiscus (mastic) and Coriander Triphala on reflux symptoms compared to omeprazole in a double-blinded randomized clinical trial.
Methods: In a double-blinded, multicenter, randomized clinical trial, we assessed the effects of Pistacia lentiscus L., Coriander Triphala, and omeprazole on the symptoms of GERD in Tabriz, Iran, in 2018 - 2019. Thus, 105 patients with GERD symptoms were assigned randomly to three groups as group A (Pistacia lentiscus L., 1000 mg/TDS), group B (Coriander Triphala, 1000 mg/TDS), and group C (omeprazole, 20 mg/day plus five placebo capsules per day). The assessments were done at the beginning and the end of the study using FSSG, VAS, RS, and GERD-HRQL questionnaires.
Results: In the beginning, no significant differences were observed between the groups in the background characteristics. There was no statistically significant difference between Pistacialentiscus, Coriander Triphala, and omeprazole in the improvement of FSSG, VAS, GERD-HRQL, and reflux scores. In all groups, the FFSG, VAS, reflux, and GERD-HRQL scores significantly decreased and improved after four weeks of intervention compared to the respective baselines. The FSSG score improvements after four weeks of intervention were 73.68%, 83.33%, and 68.62%, in groups A, B, and C, respectively. The VAS score improvements were 66.66%, 75.00%, and 62.50% in groups A, B, and C, respectively. Improvements in GERD-HRQL were 90.00%, 91.28%, and 82.00%, in groups A, B, and C, respectively. Reflux improvements were 66.66%, 80.00%, and 66.66% in groups A, B, and C, respectively.
Conclusions: The results showed that Pistacia lentiscus and Coriander Triphala are as effective as omeprazole in the treatment of GERD.
Arezoo Moini Jazani; Hossein Nazemiyeh; Mojgan Tansaz; Homayoun Sadeghi Bazargani; Seyed Mohammad Bagher Fazljou; Ramin Nasimi Doost Azgomi; Kobra Hamdi
Volume 20, Issue 5 , 2018, Pages 1-11
Abstract
Background: Polycystic ovary syndrome (PCOS)-induced oligomenorrhea can leave psychological and non-psychological impacts on women. Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles. Objectives: We planned a study to compare the effects ...
Read More
Background: Polycystic ovary syndrome (PCOS)-induced oligomenorrhea can leave psychological and non-psychological impacts on women. Among the proposed strategies for its treatment, herbal medications are of importance due to favorable effect profiles. Objectives: We planned a study to compare the effects of Celery and Anise combination (CAC) and metformin (met.) on oligomen- orrhea in PCOS patients. Methods: We conducted a triple-blind, Randomized clinical trial on 72 patients that were randomly allocated into two equal groups to receive six capsules of either CAC (750 mg each) or met. (250 mg each) at three separate doses for 15 days beginning from the follic- ular phase. If the bleeding occurred, three capsules of either placebo or met. would be administered daily during the menstruation phase, and then the follicular phase step with six capsules would be repeated. If the bleeding did not occur, three capsules of eitherplacebo or met. would be administered each day for 15 days. The regularity of menstrual bleeding as the primary outcome, as well as testosterone, luteinizing hormone/follicular stimulating hormone ratio (LH/FSH), and complications, was assessed before and after the three cycles. Results: The mean age ± standard deviation of patients was 26.5 ± 6.1. The mean Body Mass Index was 26.4 ± 3.5. CAC significantly improved oligomenorrhea (58.3% vs. 25%, P < 0.01), increased bleeding episodes (P = 0.003), and reduced testosterone (mean dif- ference: 0.16 vs. -0.02, P = 0.005) and LH/FSH (mean difference: 0.75 vs. -0.08, P = 0.002) without any major side effects compared to met.Conclusions: We showed that Celery and Anise combination could regulate menstrual cycles and improve oligomenorrhea in poly- cystic ovary syndrome patients superiorly to metformin.
